Dissociated incretin hormone response to protein versus fat ingestion in obese subjects.
Research output: Contribution to journal › Article
Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers (BMI >30kg/m(2) ; n=12) and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat vs. protein. However, the total 300 min GIP response was greater after fat than after protein ingestion (20.3±3.9 vs. 10.0±2.8 nmol/l x 300 min; P=0.026), whereas the 300 min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300 min GIP secretion is more pronounced after fat than protein ingestion.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Diabetes, Obesity and Metabolism|
|Publication status||Published - 2011|
Related research output
Ola Lindgren, 2012, Clinical Sciences, Lund University. 88 p.
Research output: Thesis › Doctoral Thesis (compilation)