Dissociated incretin hormone response to protein versus fat ingestion in obese subjects.

Research output: Contribution to journalArticle

Abstract

Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers (BMI >30kg/m(2) ; n=12) and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat vs. protein. However, the total 300 min GIP response was greater after fat than after protein ingestion (20.3±3.9 vs. 10.0±2.8 nmol/l x 300 min; P=0.026), whereas the 300 min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300 min GIP secretion is more pronounced after fat than protein ingestion.

Details

Authors
Organisations
External organisations
  • University of Copenhagen
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
Original languageEnglish
Pages (from-to)863-865
JournalDiabetes, Obesity and Metabolism
Volume13
Publication statusPublished - 2011
Publication categoryResearch
Peer-reviewedYes

Related research output

Ola Lindgren, 2012, Clinical Sciences, Lund University. 88 p.

Research output: ThesisDoctoral Thesis (compilation)

View all (1)