Distribution and impact on quality of life of the pain modalities assessed by the King's Parkinson's disease pain scale

Research output: Contribution to journalArticle

Abstract

In Parkinson's disease, pain is a prevalent and complex symptom of diverse origin. King's Parkinson's disease pain scale, assesses different pain syndromes, thus allowing exploration of its differential prevalence and influence on the health-related quality of life of patients. Post hoc study 178 patients and 83 matched controls participating in the King's Parkinson's disease pain scale validation study were used. For determining the respective distribution, King's Parkinson's disease pain scale items and domains scores = 0 meant absence and ≥1 presence of the symptom. The regular scores were used for the other analyses. Health-related quality of lifewas evaluated with EQ-5D-3L and PDQ-8 questionnaires. Parkinson's disease patients experienced more pain modalities than controls. In patients, Pain around joints (King's Parkinson's disease pain scale item 1) and Pain while turning in bed (item 8) were the most prevalent types of pain, whereas Burning mouth syndrome (item 11) and Pain due to grinding teeth (item 10) showed the lowest frequency. The total number of experienced pain modalities closely correlated with the PDQ-8 index, but not with other variables. For all pain types except Pain around joints (item 1) and pain related to Periodic leg movements/RLS (item 7), patients with pain had significantly worse health-related quality of life. The influence of pain, as a whole, on the health-related quality of life was not remarkable after adjustment by other variables. When the particular types of pain were considered, adjusted by sex, age, and Parkinson's disease duration, pain determinants were different for EQ-5D-3L and PDQ-8. King's Parkinson's disease pain scale allows exploring the distribution of the diverse syndromic pain occurring in Parkinson's disease and its association with health-related quality of life.

Details

Authors
  • Pablo Martinez-Martin
  • Jose Manuel Rojo-Abuin
  • Alexandra Rizos
  • Carmen Rodriguez-Blazquez
  • Claudia Trenkwalder
  • Lauren Perkins
  • Anna Sauerbier
  • Per Odin
  • Angelo Antonini
  • Kallol Ray Chaudhuri
Organisations
External organisations
  • King's College Hospital
  • Paracelsus-Elena-Klinik Kassel
  • Central Hospital Bremerhaven
  • Carlos III University of Madrid
  • Spanish Council of Scientific Research (CSIC)
  • King's College London
  • San Camillo Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Article number8
Pages (from-to)1-6
Journalnpj Parkinson's Disease
Volume3
Publication statusPublished - 2017
Publication categoryResearch
Peer-reviewedYes