Disturbed pubertal growth in girls treated for acute lymphoblastic leukemia

Research output: Contribution to journalArticle


Pubertal growth was studied in 10 girls previously treated for acute lymphoblastic leukemia. The average age at menarche was 12.2 years, which is significantly lower (p less than 0.01) than the expected 13.1 years. Compared with normal girls, these girls showed a subnormal (p less than 0.05) peak height velocity during the second year before menarche. The remaining growth before menarche as well as the total postmenarchal growth was close to the normal average. The average final standing height was 1 SD less than what would be expected from their height 1 year after the cessation of therapy. A relative growth hormone deficiency in combination with early onset of puberty could account for this loss in final height.


Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pediatrics


  • acute lymphoblastic leukemia, children, growth, puberty, growth hormone, irradiation, menarche
Original languageEnglish
Pages (from-to)1-5
JournalPediatric Hematology & Oncology
Issue number1
Publication statusPublished - 1987
Publication categoryResearch