DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets.

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Abstract

Insulin secretion is enhanced upon the binding of Glucagon-like peptide-1 (GLP-1) to its receptor (GLP1R) in pancreatic β cells. Although a reduced expression of GLP1R in pancreatic islets from type 2 diabetic patients and hyperglycaemic rats has been established, it is still unknown if this is caused by differential DNA methylation of GLP1R in pancreatic islets of type 2 diabetic patients.

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  • Medical Genetics
Original languageEnglish
Article number76
JournalBMC Medical Genetics
Volume14
Issue numberJul,23
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes

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Related research output

Hall, E., 2015, Epigenetics and Diabetes. 59 p.

Research output: ThesisDoctoral Thesis (compilation)

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