DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts.

Research output: Contribution to journalArticle


Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.


  • Leonidas Chouliaras
  • Gunter Kenis
  • Pieter Jelle Visser
  • Philip Scheltens
  • Magda Tsolaki
  • Roy W Jones
  • Patrick G Kehoe
  • Caroline Graff
  • Nicola G Girtler
  • Åsa Wallin
  • Marcel Olde Rikkert
  • Luiza Spiru
  • Lyzel S Elias-Sonnenschein
  • Inez Hgb Ramakers
  • Ehsan Pishva
  • Jim van Os
  • Harry Wm Steinbusch
  • Frans Rj Verhey
  • Daniel LA van den Hove
  • Bart Pf Rutten
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Pages (from-to)533-537
Issue number4
Publication statusPublished - 2015
Publication categoryResearch