Do the solvent properties affect the propensity for self-association of α-cyclodextrin? Insights from NMR self-diffusion

Research output: Contribution to journalArticle

Abstract

Whether cyclodextrins (CDs) self-aggregate or not in solution is an interesting and timely scientific question. Yet, we are far from a scientific consensus as regards the nature of the phenomenon. Those who are in favor of the formation of CD aggregates justify the phenomenon by the presence of H-bonds, occurring between the hydroxyl groups located at both rims of cyclodextrins. To gain further insight with regard to the importance of these intermolecular CD-CD interactions, a systematic study of 1H NMR self-diffusion of α-cyclodextrin in binary mixtures of deuterated DMSO and water, at different mole fractions, has been carried out. The choice of these solvents was made based on their different degree of polarity and the fact that they are miscible at any molar ratio. The experimental α-CD diffusion coefficients scale with the solution viscosity. Moreover, hydrodynamic radii of α-CD are independent of the solvent composition. No evidence of α-cyclodextrin aggregation at any DMSO mole fraction is found. Finally, experimental diffusion data are compared with those obtained from atomic level hydrodynamic calculations. In addition, diffusion coefficients of heavy water and DMSO in binary mixed solvents are also measured and analyzed. The obtained diffusion coefficients for DMSOd6 and D2O show a minimum at the eutectic composition and depend on the solution viscosity. The experimental results are compared with published molecular dynamic simulations.

Details

Authors
Organisations
External organisations
  • University of Coimbra
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Analytical Chemistry

Keywords

  • DMSO, PFG NMR, Self-diffusion coefficients, Water, α-Cyclodextrin
Original languageEnglish
Article number111869
JournalJournal of Molecular Liquids
Volume295
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes