Does nociceptin play a role in pain disorders in man?

Research output: Contribution to journalArticle

Abstract

Nociceptin-immunoreactive cellbodies were detected in the human trigeminal ganglion, while no such fibers were identified in the temporal artery or in dermal tissue from the neck region. In four healthy subjects receiving nociceptin into the temporal muscle in an open labeled design no pain was detected. In 10 healthy subjects who received 200 pmol of nociceptin into tender non-dominant trapezius muscles in a placebo-controlled, randomized, balanced, and double-blinded design local tenderness increased (P = 0.025) while no pain was noted. Thus, the action of nociceptin should be searched for in the trigeminal ganglion and/or in the central nervous system (CNS). (C) 2002 Elsevier Science Inc. All rights reserved.

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Authors
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Respiratory Medicine and Allergy

Keywords

  • myofascial pain, myofascial tenderness, intra-muscular, human, injection, nociceptin
Original languageEnglish
Pages (from-to)1581-1587
JournalPeptides
Volume23
Issue number9
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes