Downregulation of Angiogenesis Factors, VEGF and PDGF, after Rapid IgE Desensitization and Oral Immunotherapy in Children with Food Allergy

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Abstract

Background. Angiogenesis has a key role in several conditions and is regulated by several factors such as the platelet-derived growth factor (PDGF) or the vascular endothelial growth factor (VEGF). The goal of this study was to investigate the possible role of PDGF and VEGF in a group of patients with severe food allergy. Methods. We design a prospective longitudinal study (n = 30) with patients with persistent cow's milk proteins (CMP) allergy. After achieving a CMP rush desensitization protocol, a clinical followup including SPT and blood samples to determine sIgE, protein levels, PDGF, and VEGF-A and a panel of the most representative Th-1, Th-2, T-reg, and Th-17 cytokines were also monitored. Results. Baseline levels of PDGF and VEGF in the CMP allergic patients (1170 pg/mL and 253 pg/mL) were different compared to those nonallergic CMP control subjects (501 pg/mL and 108 pg/mL). Both PDGF and VEGF were significantly downregulated (P < 0.05) 6 months after completion of the CMP desensitization process and remained significantly decreased 12 months later. Conclusion. The present study shows a significant increase of PDGF and VEGF in anaphylaxis suffering children compared to a control group. Interestingly, both VEGF and PDGF were significantly downregulated after completing a full CMP rush IgE desensitization.

Details

Authors
  • Paloma Poza-Guedes
  • Yvelise Barrios
  • Victoria Fuentes
  • Andres Franco
  • Inmaculada Sanchez-Machin
  • Elena Alonso
  • Ruperto Gonzalez Perez
  • Sonsoles Infante
  • Lydia Zapatero
  • Victor Matheu
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Surgery
  • Neurology
Original languageEnglish
Article number372567
JournalBioMed Research International
Volume2014
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes