D-serine in the developing human central nervous system

Research output: Contribution to journalArticle


To elucidate the role of D-serine in human central nervous system, we analyzed D-serine, L-serine, and glycine concentrations in cerebrospinal fluid of healthy children and children with a defective L-serine biosynthesis (3-phosphoglycerate dehydrogenase deficiency). Healthy children showed high D-serine concentrations immediately after birth, both absolutely and relative to glycine and L-serine, declining to low values at infancy. D-Serine concentrations were almost undetectable in untreated 3-phosphoglycerate dehydrogenase-deficient patients. In one patient treated prenatally, D-serine concentration was nearly normal at birth and the clinical phenotype was normal. These observations suggest a pivotal role for D-serine in normal and aberrant human brain development.


  • Sabine A. Fuchs
  • Lambertus Dorland
  • Monique G. De Sain-Van Der Velden
  • Margriet Hendriks
  • Leo W.J. Klomp
  • Ruud Berger
  • Tom J. De Koning
External organisations
  • University Medical Center Utrecht
  • Wilhelmina Children’s Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Pages (from-to)476-480
Number of pages5
JournalAnnals of Neurology
Issue number4
Publication statusPublished - 2006 Oct 1
Publication categoryResearch
Externally publishedYes