Dual versus triple therapy in eradication of Helicobacter pylori

Research output: Contribution to journalArticle

Abstract

Background/Aims: Duodenal ulcers should be treated by eradication of Helicobacter pylori. This study compared the efficacy of a proton pump inhibitor together with one or two antibiotics in eradication therapy, Methodology: 177 patients who were H. pylori positive were randomized to receive 14 days of either: lansoprazole 30mg bd and amoxicillin 1g bd (LA), omeprazole 20mg bd and amoxicillin 1g bd (OA) or lansoprazole 30mg bd, amoxicillin 1g bd and clarithromycin 500mg bd (LAC). The efficacy was assessed at four weeks and at six months after the end of treatment. Biopsies were taken for culture and bacterial sensitivity testing at inclusion and at four weeks after the end of treatment. Results: 149 patients were evaluated for efficacy. The eradication rate was significantly higher in LAC (96%) compared to LA (51%) and OA (64%) treatments (P<0.001). At baseline 17%, 21% and 19% of the patients in the LA, OA and LAC groups, respectively, were resistant to metronidazole and only one patient was resistant to clarithromycin. Post-treatment, four patients had acquired metronidazole resistance. Conclusions: LAC is more effective than LA and CA for eradication of H. pylori in duodenal ulcer disease.

Details

Authors
  • Bertil Öhlin
  • A Cederberg
  • T Kjellin
  • E Kullman
  • K Melen
  • Christer Staël von Holstein
  • M Thoring
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Surgery

Keywords

  • triple therapy, duodenal ulcer, H. pylori infection, eradication therapy
Original languageEnglish
Pages (from-to)172-175
JournalHepato-Gastroenterology
Volume49
Issue number43
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes