Dynamic assembly of molecularly imprinted polymer nanoparticles

Research output: Contribution to journalArticle


Manipulation of specific binding and recycling of materials are two important aspects for practical applications of molecularly imprinted polymers. In this work, we developed a new approach to control the dynamic assembly of molecularly imprinted nanoparticles by surface functionalization. Molecularly imprinted polymer nanoparticles with a well-controlled core-shell structure were synthesized using precipitation polymerization. The specific binding sites were created in the core during the first step imprinting reaction. In the second polymerization step, epoxide groups were introduced into the particle shell to act as an intermediate linker to immobilize phenylboronic acids, as well as to introduce cis-diol structures on surface. The imprinted polymer nanoparticles modified with boronic acid and cis-diol structures maintained high molecular binding specificity, and the nanoparticles could be induced to form dynamic particle aggregation that responded to pH variation and chemical stimuli. The possibility of modulating molecular binding and nanoparticle assembly in a mutually independent fashion can be exploited in a number of applications where repeated use of precious nanoparticles is needed.


External organisations
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Polymer Chemistry
  • Biochemistry and Molecular Biology


  • Boronic acid, Dynamic assembly, Molecular imprinting, Molecular recognition, Nanoparticles
Original languageEnglish
Pages (from-to)463-471
Number of pages9
JournalJournal of Colloid and Interface Science
Publication statusPublished - 2018 Jan 1
Publication categoryResearch