EANM practical guidance on uncertainty analysis for molecular radiotherapy absorbed dose calculations

Research output: Contribution to journalArticle

Abstract

A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed dose in a site of interest as the product of the cumulated activity and a dose factor. In turn, the cumulated activity is given by the area under a time–activity curve derived from a time sequence of activity values. Each activity value is obtained in terms of a count rate, a calibration factor and a recovery coefficient (a correction for partial volume effects). The method to determine the recovery coefficient and the dose factor, both of which are dependent on the size of the volume of interest (VOI), are described. Consideration is given to propagating estimates of the quantities concerned and their associated uncertainties through the dosimetry chain to obtain an estimate of mean absorbed dose in the VOI and its associated uncertainty. This approach is demonstrated in a clinical example.

Details

Authors
Organisations
External organisations
  • Royal Marsden NHS Foundation Trust
  • National Physical Laboratory
  • University of Ulm
  • Erasmus University Medical Center
  • Institute of Cancer Research London
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • Dosimetry, Uncertainty analysis
Original languageEnglish
Pages (from-to)2456-2474
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume45
Issue number13
Early online date2018 Sep 14
Publication statusPublished - 2018 Dec
Publication categoryResearch
Peer-reviewedYes