Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets

Research output: Contribution to journalArticle

Abstract

We tested the hypothesis that controlled hypoxemic resuscitation improves early cerebral metabolic and electrophysiological recovery in hypoxic newborn piglets. Severely hypoxic anesthetized piglets were randomly divided into three resuscitation groups: hypoxemic, 21% O2, and 100% O2 groups (8 in each group). The hypoxemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%). Base excess (BE) reached -22 +/- 1 mM at the end of hypoxia. During a 2-h resuscitation period, no significant differences in time to recovery of electroencephalography (EEG), quality of EEG at recovery, or extracellular hypoxanthine concentrations in the cerebral cortex and striatum were found among the groups. BE and plasma hypoxanthine, however, normalized significantly more slowly during controlled hypoxemic resuscitation than during resuscitation with 21 or 100% O2. We conclude that early brain recovery during controlled hypoxemic resuscitation was as efficient as, but not superior to, recovery during resuscitation with 21 or 100% O2. The systemic metabolic recovery from hypoxia, however, was delayed during controlled hypoxemic resuscitation.

Details

Authors
  • B A Feet
  • N C Brun
  • Lena Hellström-Westas
  • Niels W Svenningsen
  • G Greisen
  • O D Saugstad
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physiology

Keywords

  • asphyxia, electroencephalography, near-infrared spectrophotometry, hypoxanthine, newborn piglets
Original languageEnglish
Pages (from-to)1208-1216
JournalJournal of Applied Physiology
Volume84
Issue number4
Publication statusPublished - 1998
Publication categoryResearch
Peer-reviewedYes