Early presentation of osteonecrosis in acute lymphoblastic leukemia: Two children from the Nordic and Baltic cohort

Research output: Contribution to journalArticle


Osteonecrosis (ON) is usually considered treatment related in patients with acute lymphoblastic leukemia (ALL). We report two patients with presentation of ON at the time of ALL diagnosis. Both were females and diagnosed with ALL at age 8 and 14 years. In the latter, some symptoms and radiologically verified ON in both knees were still present after the end of ALL therapy. No pediatric patients have previously been reported with ON presenting before initiation of ALL therapy.


  • Signe Sloth Mogensen
  • Arja Harila-Saari
  • Thomas Leth Frandsen
  • Päivi M Lähteenmäki
  • Anders Castor
  • Ia Kohonen
  • Kjeld Schmiegelow
  • Outi Mäkitie
External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Gastroenterology and Hepatology


  • Journal Article
Original languageEnglish
Article numbere26624
JournalPediatric Blood & Cancer
Issue number11
Early online date2017 May 18
Publication statusPublished - 2017
Publication categoryResearch
Externally publishedYes