Early vascular ageing in translation: from laboratory investigations to clinical applications in cardiovascular prevention.

Research output: Contribution to journalReview article

Abstract

The ageing of the vascular tree is a fundamental reflection of biological ageing in general and a determinant of organ function. In the arterial wall this is characterized by a reduction in the elastin content, as well as by an increased content of collagen and its cross-linkages, leading to increased arterial stiffness and elevated central as well as brachial blood pressure, accompanied by increased SBP variability. In recent years a better understanding of these processes have led to the proposal of a condition named early vascular ageing (EVA) in patients with increased arterial stiffness for their age and sex. This is a condition that could increase cardiovascular risk and is associated with various degrees of cognitive dysfunction, as well as other features of biological ageing. This brief review aims to give an update on EVA and how the concept can be used in clinical practice.

Details

Authors
  • Peter Nilsson
  • Pierre Boutouyrie
  • Pedro Cunha
  • Vasilios Kotsis
  • Krzysztof Narkiewicz
  • Gianfranco Parati
  • Ernst Rietzschel
  • Angelo Scuteri
  • Stephane Laurent
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
Original languageEnglish
Pages (from-to)1517-1526
JournalJournal of Hypertension
Volume31
Issue number8
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes