EEG depression and germinal layer haemorrhage in the newborn

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EEG depression and germinal layer haemorrhage in the newborn. / Greisen, G; Hellström-Westas, Lena; Lou, H; Rosén, Ingmar; Svenningsen, N W.

In: Acta Paediatrica Scandinavica, Vol. 76, No. 3, 1987, p. 519-525.

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Greisen, G, Hellström-Westas, L, Lou, H, Rosén, I & Svenningsen, NW 1987, 'EEG depression and germinal layer haemorrhage in the newborn', Acta Paediatrica Scandinavica, vol. 76, no. 3, pp. 519-525. https://doi.org/10.1111/j.1651-2227.1987.tb10509.x

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Greisen, G ; Hellström-Westas, Lena ; Lou, H ; Rosén, Ingmar ; Svenningsen, N W. / EEG depression and germinal layer haemorrhage in the newborn. In: Acta Paediatrica Scandinavica. 1987 ; Vol. 76, No. 3. pp. 519-525.

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TY - JOUR

T1 - EEG depression and germinal layer haemorrhage in the newborn

AU - Greisen, G

AU - Hellström-Westas, Lena

AU - Lou, H

AU - Rosén, Ingmar

AU - Svenningsen, N W

PY - 1987

Y1 - 1987

N2 - Amplitude integrated EEG (aEEG) recordings from 32 mechanically ventilated infants, gestational age 32 weeks or less, were analysed. All recordings were started within 24 h of birth and continued for at least 50 h. Germinal layer haemorrhage (GLH) was diagnosed by repeated ultrasonography. In six infants neither GLH nor hypocalcaemia were diagnosed; aEEG in these infants rapidly became more active after birth: at 30 h of age continuous background activity was present for more than 20% of the time, and a seizure-like pattern was exceptional. In seven infants without GLH but with hypocalcaemia and other signs of metabolic derangement, continuous background activity appeared later and seizure-like activity was frequent. In the infants with GLH, depression of the background activity was apparent. This finding was particularly distinct in the presence of severe haemorrhages. Four infants developed GLH after 30 h of age. All these infants had depressed aEEG before the development of GLH, with less than 20% continuous activity at 30 h of age. In ten infants an analysis of the aEEG during the occurrence of GLH was possible. In six of these, cortical electrical activity decreased. Due to the limitation of GLH timing, it was not possible to decide whether this decrease closely preceded or followed GLH. We suggest that GLH primarily occurs in brains with a preceding metabolic and neurophysiologic abnormality, and that further functional deterioration is caused by the most severe haemorrhages.

AB - Amplitude integrated EEG (aEEG) recordings from 32 mechanically ventilated infants, gestational age 32 weeks or less, were analysed. All recordings were started within 24 h of birth and continued for at least 50 h. Germinal layer haemorrhage (GLH) was diagnosed by repeated ultrasonography. In six infants neither GLH nor hypocalcaemia were diagnosed; aEEG in these infants rapidly became more active after birth: at 30 h of age continuous background activity was present for more than 20% of the time, and a seizure-like pattern was exceptional. In seven infants without GLH but with hypocalcaemia and other signs of metabolic derangement, continuous background activity appeared later and seizure-like activity was frequent. In the infants with GLH, depression of the background activity was apparent. This finding was particularly distinct in the presence of severe haemorrhages. Four infants developed GLH after 30 h of age. All these infants had depressed aEEG before the development of GLH, with less than 20% continuous activity at 30 h of age. In ten infants an analysis of the aEEG during the occurrence of GLH was possible. In six of these, cortical electrical activity decreased. Due to the limitation of GLH timing, it was not possible to decide whether this decrease closely preceded or followed GLH. We suggest that GLH primarily occurs in brains with a preceding metabolic and neurophysiologic abnormality, and that further functional deterioration is caused by the most severe haemorrhages.

KW - preterm infant

KW - cerebral haemorrhage

KW - electroencephalogram

KW - hypocalcaemia

U2 - 10.1111/j.1651-2227.1987.tb10509.x

DO - 10.1111/j.1651-2227.1987.tb10509.x

M3 - Article

VL - 76

SP - 519

EP - 525

JO - Acta Pædiatrica

JF - Acta Pædiatrica

SN - 1651-2227

IS - 3

ER -