Effect of iodixanol particle size on the mechanical properties of a PMMA based bone cement.

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Iodixanol (IDX) is a water soluble opacifier widely used in radiographical examinations of blood vessels and neural tissue, and it has been suggested as a potential contrast media in acrylic bone cement. The effect of the iodixanol particle size on the polymerisation process of the bone cement, the molecular weight, and the quasi-static mechanical properties have been investigated in this article. The investigation was performed using radiolucent Palacos powder mixed with 8 wt% of iodixanol with particle sizes ranging from 3 to 20 mu m MMD, compared with commercial Palacos R (15 wt% ZrO2) as control. Tensile, compressive and flexural tests showed that smaller particles (groups with 3, 4, and 5 mu m particles) resulted in significantly lower mechanical properties than the larger particles (groups with 15, 16, and 20 mu m particles). There was no difference in molecular weight between the groups. The thermographical investigation showed that the IDX cements exhibit substantially lower maximum temperatures than Palacos R, with the 4 mu m IDX group having the lowest maximum temperature. The isothermal and the constant rate differential scanning calorimetry (DSC) did not show any difference in polymerisation heat (Delta H) or glass transition temperature (T-g) between radiolucent cement, or cement containing either IDX, or ZrO2. The findings show that the particle size for a bone cement containing iodixanol should be above 8 mu m MMD.


  • Fred Kjellson
  • Saba Abdulghani
  • K Tanner
  • Ian McCarthy
  • Lars Lidgren
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Materials
Original languageEnglish
Pages (from-to)1043-1051
JournalJournal of Materials Science: Materials in Medicine
Publication statusPublished - 2007
Publication categoryResearch

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