Effect of late prophylaxis in hemophilia on joint status: A randomized trial

Research output: Contribution to journalArticle

Abstract

Essentials: High-quality data are lacking on use of prophylaxis in adults with hemophilia and arthropathy. SPINART was a 3-year randomized clinical trial of late/tertiary prophylaxis vs on-demand therapy. Prophylaxis improved function, quality of life, activity and pain but not joint structure by MRI. Prophylaxis improves function but must start before joint bleeding onset to prevent arthropathy. Summary: Background: Limited data exist on the impact of prophylaxis on adults with severe hemophilia A and pre-existing joint disease. Objectives: To describe 3-year bleeding, joint health and structure, health-related quality-of-life (HRQoL) and other outcomes from the open-label, randomized, multinational SPINART study. Patients/Methods: Males aged 12-50 years with severe hemophilia A, ≥ 150 factor VIII exposure days, no inhibitors and no prophylaxis for > 12 consecutive months in the past 5 years were randomized to sucrose-formulated recombinant FVIII prophylaxis or on-demand therapy (OD). Data collected included total and joint bleeding events (BEs), joint structure (magnetic resonance imaging [MRI]), joint health (Colorado Adult Joint Assessment Scale [CAJAS]), HRQoL, pain, healthcare resource utilization (HRU), activity, and treatment satisfaction. Results: Following 3 years of prophylaxis, adults maintained excellent adherence, with a 94% reduction in BEs despite severe pre-existing arthropathy; 35.7% and 76.2% of prophylaxis participants were bleed-free or had fewer than two BEs per year, respectively. As compared with OD, prophylaxis was associated with improved CAJAS scores (least squares [LS] mean, - 0.31 [n = 42] versus + 0.63 [n = 42]) and HAEMO-QoL-A scores (LS mean, + 3.98 [n = 41] versus - 6.00 [n = 42]), less chronic pain (50% decrease), and approximately two-fold less HRU; activity, Euro QoL-5D-3L (EQ-5D-3L) scores and satisfaction scores also favored prophylaxis. However, MRI score changes were not different for prophylaxis versus OD (LS mean, + 0.79 [n = 41] versus + 0.96 [n = 38]). Conclusions: Over a period of 3 years, prophylaxis versus OD in adults with severe hemophilia A and arthropathy led to decreased bleeding, pain, and HRU, better joint health, activity, satisfaction, and HRQoL, but no reduction in structural arthropathy progression, suggesting that pre-existing joint arthropathy may be irreversible.

Details

Authors
  • M. J. Manco-Johnson
  • B. Lundin
  • S. Funk
  • C Peterfy
  • D. Raunig
  • M. Werk
  • C L Kempton
  • M. T Reding
  • S. Goranov
  • L. Gercheva
  • L Rusen
  • M. V. Uscatescu
  • Marina Pierdominici
  • S. Engelen
  • J. Pocoski
  • D. Walker
  • W Hong
Organisations
External organisations
  • Skåne University Hospital
  • Spire Sciences, Inc.
  • ICON Medical Imaging
  • Charité Universitätsmedizin Berlin
  • Emory University
  • University of Minnesota system
  • Medical University of Plovdiv
  • Fundeni Clinical Institute
  • Hospital JM Ramos Mejia
  • Bayer Corporation, USA
  • University of Colorado School of Medicine
  • University Hospital St. Marina – Varna
  • Sanador hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology
  • Cardiac and Cardiovascular Systems

Keywords

  • Arthropathy, Clinical trial, Hemophilia A, Magnetic resonance imaging, Prophylaxis, Quality of life
Original languageEnglish
Pages (from-to)2115-2124
JournalJournal of Thrombosis and Haemostasis
Volume15
Issue number11
Publication statusPublished - 2017 Nov
Publication categoryResearch
Peer-reviewedYes