Effect of oxygen therapy on myocardial salvage in ST elevation myocardial infarction: the randomized SOCCER trial

Research output: Contribution to journalArticle


OBJECTIVE: Recent studies suggest that administration of O2 in patients with acute myocardial infarction may have negative effects. With the use of cardiac MRI (CMR), we evaluated the effects of supplemental O2 in patients with ST elevation myocardial infarction (STEMI) accepted for acute percutaneous coronary intervention (PCI).

MATERIALS AND METHODS: This study was a randomized-controlled trial conducted at two university hospitals in Sweden. Normoxic STEMI patients were randomized in the ambulance to either supplemental O2 (10 l/min) or room air until the conclusion of the PCI. CMR was performed 2-6 days after the inclusion. The primary endpoint was the myocardial salvage index assessed by CMR. The secondary endpoints included infarct size and myocardium at risk.

RESULTS: At inclusion, the O2 (n=46) and air (n=49) patient groups had similar patient characteristics. There were no significant differences in myocardial salvage index [53.9±25.1 vs. 49.3±24.0%; 95% confidence interval (CI): -5.4 to 14.6], myocardium at risk (31.9±10.0% of the left ventricle in the O2 group vs. 30.0±11.8% in the air group; 95% CI: -2.6 to 6.3), or infarct size (15.6±10.4% of the left ventricle vs. 16.0±11.0%; 95% CI: -4.7 to 4.1).

CONCLUSION: In STEMI patients undergoing acute PCI, we found no effect of high-flow oxygen compared with room air on the size of ischemia before PCI, myocardial salvage, or the resulting infarct size. These results support the safety of withholding supplemental oxygen in normoxic STEMI patients.


External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
  • Other Clinical Medicine


  • STEMI, ST Elevation Myocardial Infarction, Oxygen Therapy, MSI, Myocardial Salvage Index, MRI, Magnetic Resonance Imaging
Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalEuropean Journal of Emergency Medicine
Issue number2
Early online date2016 Nov 23
Publication statusPublished - 2018
Publication categoryResearch

Related research output

Ardavan Khoshnood, 2018 Oct 19, In : BMC Emergency Medicine. 18, 35.

Research output: Contribution to journalDebate/Note/Editorial

Sepehrvand, N., James, S. K., Stub, D., Ardavan Khoshnood, Ezekowitz, J. A. & Hofmann, R., 2018, In : Heart. 104, 20, p. 1691-1698

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Related activities

Khoshnood, A. (Invited speaker)
2018 Mar 9

Activity: Talk or presentationInvited talk

Khoshnood, A. (Speaker)
2017 Oct 26

Activity: Talk or presentationPresentation

Khoshnood, A. (Presenter)
2017 May 19

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Related prizes

Ardavan Khoshnood (Recipient), 2016

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