Effect of two kinds of pectin and guar gum on 1,2-dimethylhydrazine initiation of colon tumors and on fecal beta-glucuronidase activity in the rat

Research output: Contribution to journalArticle

Abstract

The effect of 5% low-methoxylated pectin, high-methoxylated pectin, and guar gum on 1,2-dimethylhydrazine initiation of colon cancer was investigated using groups of 30 rats. The growth of the rats in the different groups was very similar to that of control group fed a fiber-free diet. Both kinds of pectin increased the multiplicity of color tumors, whereas guar gum did not significantly influence carcinogenesis. Bacterial beta-glucuronidase activity in feces and colonic content was the same in pectin-fed rats and controls but significantly lower in the guar gum group. Thus, it was not related to the number of tumors in each group.

Details

Authors
  • H G Bauer
  • N G Asp
  • A Dahlqvist
  • P E Fredlund
  • M Nyman
  • R Oste
Organisations
External organisations
  • Skåne University Hospital
  • Lund University, Food Technology
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Nutrition and Dietetics

Keywords

  • Adenocarcinoma/chemically induced, Animals, Bacteria/enzymology, Body Weight, Cellulose/pharmacology, Colonic Neoplasms/chemically induced, Dietary Fiber/pharmacology, Dimethylhydrazines/toxicity, Feces/analysis, Glucuronidase/metabolism, Male, Methylhydrazines/toxicity, Pectins/pharmacology, Rats
Original languageEnglish
Pages (from-to)2518-23
Number of pages6
JournalCancer Research
Volume41
Issue number6
Publication statusPublished - 1981 Jun
Publication categoryResearch
Peer-reviewedYes