Effects of intravenous diazepam and thiopental on the vestibulo-ocular reflex in man

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Effects of intravenous diazepam and thiopental on the vestibulo-ocular reflex in man. / Schalén, L; Korttila, K; Magnusson, M; Padoan, S; Pyykko, Ilmari.

In: Acta Oto-Laryngologica, Vol. 108, No. S468, 1989, p. 165-9.

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Schalén, L ; Korttila, K ; Magnusson, M ; Padoan, S ; Pyykko, Ilmari. / Effects of intravenous diazepam and thiopental on the vestibulo-ocular reflex in man. In: Acta Oto-Laryngologica. 1989 ; Vol. 108, No. S468. pp. 165-9.

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TY - JOUR

T1 - Effects of intravenous diazepam and thiopental on the vestibulo-ocular reflex in man

AU - Schalén, L

AU - Korttila, K

AU - Magnusson, M

AU - Padoan, S

AU - Pyykko, Ilmari

PY - 1989

Y1 - 1989

N2 - The effects of i.v. injection of diazepam 0.3 mg/kg and thiopental 6.0 mg/kg on vestibulo-ocular reflex (VOR) were studied in 9 healthy volunteers. One hour after injection of both diazepam and thiopental VOR gain was reduced and time constant shortened. Four hours after intravenous injection of diazepam the VOR gain was still significantly reduced and had not yet returned to control 8 h after injection. Although both drugs were detected in blood still 8 h after the injection, there were no longer significant effects on VOR. Moreover, individual values of VOR gain and time constant did not correlate with the blood concentrations of the drugs. Decrease of VOR gain and shortening of time constant after i.v. given diazepam and thiopental in man are interpreted as resulting from both specific effects on VOR and non-specific reduction of alertness.

AB - The effects of i.v. injection of diazepam 0.3 mg/kg and thiopental 6.0 mg/kg on vestibulo-ocular reflex (VOR) were studied in 9 healthy volunteers. One hour after injection of both diazepam and thiopental VOR gain was reduced and time constant shortened. Four hours after intravenous injection of diazepam the VOR gain was still significantly reduced and had not yet returned to control 8 h after injection. Although both drugs were detected in blood still 8 h after the injection, there were no longer significant effects on VOR. Moreover, individual values of VOR gain and time constant did not correlate with the blood concentrations of the drugs. Decrease of VOR gain and shortening of time constant after i.v. given diazepam and thiopental in man are interpreted as resulting from both specific effects on VOR and non-specific reduction of alertness.

KW - Adult

KW - Diazepam

KW - Female

KW - Humans

KW - Infusions, Intravenous

KW - Male

KW - Reflex, Vestibulo-Ocular

KW - Thiopental

KW - Time Factors

KW - Clinical Trial

KW - Controlled Clinical Trial

KW - Journal Article

KW - Randomized Controlled Trial

U2 - 10.3109/00016488909139039

DO - 10.3109/00016488909139039

M3 - Article

C2 - 2635496

VL - 108

SP - 165

EP - 169

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

SN - 1651-2251

IS - S468

ER -