Effects of neurokinin receptor antagonists on L-dopa induced bladder hyperactivity in normal conscious rats.

Research output: Contribution to journalArticle

Abstract

PURPOSE: The urodynamic effects of intrathecal neurokinin (NK) receptor blockade on L-dopa-induced bladder hyperactivity were investigated in a rat model. MATERIALS AND METHODS: Continuous cystometry was performed in normal, conscious, female Sprague-Dawley rats. RESULTS: In rats pretreated with intraperitoneal carbidopa 50 mg./kg., intraperitoneal L-dopa 50 mg./kg. caused bladder hyperactivity that could be attenuated by intrathecal administration of the NK1 receptor selective antagonist SR 140,333 (2 nmol.), whereas the NK2 receptor selective antagonist SR 48,968 (2 nmol.) failed to do so. Combination of SR 140,333 (2 nmol.) and SR 48,968 (2 nmol.), which by itself decreased micturition pressure, practically abolished the L-dopa-induced hyperactivity. CONCLUSIONS: The present results suggest that tachykinins, via stimulation of NK1 (and/or NK2) receptors, are involved in L-dopa-induced bladder hyperactivity, most probably at the spinal level. This implies tachykinin involvement in the supraspinal pathways that control the sacral parasympathetic center innervating the urinary bladder. It also implies that spinal NK receptors are a possible target for drugs aimed for elimination of bladder hyperactivity mediated via these pathways.

Details

Authors
  • O Ishizuka
  • Anders Mattiasson
  • K-E Andersson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Urology and Nephrology
Original languageEnglish
Pages (from-to)1548-1551
JournalJournal of Urology
Volume154
Issue number4
Publication statusPublished - 1995
Publication categoryResearch
Peer-reviewedYes

Related research output

Osamu Ishizuka, 1996, Osamu Ishizuka, Department of Urology, Lund University Hospital, S-221 85 Lund Sweden,. 44 p.

Research output: ThesisDoctoral Thesis (compilation)

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