Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

Research output: Contribution to journalArticle

Abstract

Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics may contribute to T2D and obesity. However, there is limited information on whether fatty acids alter the genome-wide transcriptome profile in conjunction with DNA methylation patterns in human pancreatic islets. To dissect the molecular mechanisms linking lipotoxicity to impaired insulin secretion, we investigated the effects of a 48 h palmitate treatment in vitro on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
Original languageEnglish
Article number103
JournalBMC Medicine
Volume12
Issue number1
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes

Total downloads

No data available

Related research output

Hall, E., 2015, Epigenetics and Diabetes. 59 p.

Research output: ThesisDoctoral Thesis (compilation)

View all (1)