Effects of Vedolizumab Therapy on Extraintestinal Manifestations in Inflammatory Bowel Disease

Research output: Contribution to journalArticle

Abstract

Background: Approximately 15–20% of ulcerative colitis patients and 20–40% of those with Crohn’s disease experience extraintestinal manifestations (EIMs) of their inflammatory bowel disease (IBD). Clinicians who treat IBD must manage EIMs affecting multiple organs that variably correlate with intestinal disease activity. Vedolizumab is a monoclonal antibody for the treatment of IBD with a gut-selective mechanism of action. Aims: This report evaluates whether vedolizumab is an effective treatment of EIMs, given its gut-specific mechanism of action. Methods: We report 8 case studies of patients with various EIMs, including pyoderma gangrenosum, peripheral arthralgia/arthritis, axial arthropathies, erythema nodosum, and uveitis, who received vedolizumab therapy. Results: Vedolizumab therapy was effective for pyoderma gangrenosum in ulcerative colitis, uveitis, erythema nodosum, polyarticular arthropathy, and ankylosing spondylitis/sacroiliitis but did not provide sustained benefit for the treatment of pyoderma gangrenosum in a patient with Crohn’s disease. Conclusions: These cases demonstrate the potential of vedolizumab as a treatment of EIMs in patients with IBD.

Details

Authors
  • Mark Fleisher
  • Jan Marsal
  • Scott D. Lee
  • Laura E. Frado
  • Alyssa Parian
  • Burton I. Korelitz
  • Brian G. Feagan
Organisations
External organisations
  • Borland-Groover Clinic
  • University of Washington
  • Mount Sinai Hospital
  • Johns Hopkins Hospital
  • Lenox Hill Hospital
  • University of Western Ontario
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Gastroenterology and Hepatology

Keywords

  • Crohn’s disease, Extraintestinal manifestations, Inflammatory bowel disease, Ulcerative colitis
Original languageEnglish
Pages (from-to)825-833
JournalDigestive Diseases and Sciences
Volume63
Issue number4
Publication statusPublished - 2018
Publication categoryResearch
Peer-reviewedYes