Effects of whey proteins on glycaemia and insulinaemia to an oral glucose load in healthy adults; a dose-response study.

Research output: Contribution to journalArticle


Background/Objectives:Whey proteins have insulinogenic properties and the effect appears to be mediated from a postprandial plasma amino-acid (AA) response. The aim was to study the possible dose-response relationship between whey intake and glycaemic-, insulinaemic- and plasma AA responses.Subjects/Methods:Twelve healthy volunteers participated in the study. They were provided three whey protein drinks, containing 4.5, 9 or 18 g protein as breakfast meals in random order. All meals contained 25 g available carbohydrates (glucose). The same amount of glucose in water was used as reference.Results:Linear dose-response relations were found between whey protein intake and postprandial glycaemia, insulinaemia and plasma AAs. The two highest doses, 18 g and 9 g, significantly reduced postprandial glycaemia (incremental area under the curve (iAUC) 0-120 min; P< 0.05). The 18 g dose significantly increased the insulin response (iAUC 0-120 min; P<0.05). All measured plasma AAs (15 in total), except glutamic acid, responded in a dose-dependent way, and the 9 and 18 g doses resulted in significantly higher plasma levels of AAs compared with the reference.Conclusions:Whey protein affects glycaemia, insulinaemia and plasma AAs to a glucose load in a dose-dependent manner. Comparatively low doses of whey protein (9 g) reduced postprandial glycaemia significantly when added to a carbohydrate-rich meal.European Journal of Clinical Nutrition advance online publication, 1 May 2013; doi:10.1038/ejcn.2013.88.


  • Ulrika Gunnerud
  • Elin Östman
  • Inger Björck
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Nutrition and Dietetics
Original languageEnglish
Pages (from-to)749-753
JournalEuropean Journal of Clinical Nutrition
Issue number7
Publication statusPublished - 2013
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Nutrition and Food Chemistry (011001300)

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