Efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases: A systematic literature review for the 2019 update of EULAR recommendations

Research output: Contribution to journalReview article

Abstract

Aim To present a systematic literature review (SLR) on efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD), aiming to provide a basis for updating the EULAR evidence-based recommendations. Methods An SLR was performed according to the standard operating procedures for EULAR-endorsed recommendations. Outcome was determined by efficacy, immunogenicity and safety of vaccination in adult patients with AIIRD, including those receiving immunomodulating therapy. Furthermore, a search was performed on the effect of vaccinating household members of patients with AIIRD on the occurrence of vaccine-preventable infections in patients and their household members (including newborns). The literature search was performed using Medline, Embase and the Cochrane Library (October 2009 to August 2018). Results While most investigated vaccines were efficacious and/or immunogenic in patients with AIIRD, some were less efficacious than in healthy control subjects, and/or in patients receiving immunosuppressive agents. Adverse events of vaccination were generally mild and the rates were comparable to those in healthy persons. Vaccination did not seem to lead to an increase in activity of the underlying AIIRD, but insufficient power of most studies precluded arriving at definite conclusions. The number of studies investigating clinical efficacy of vaccination is still limited. No studies on the effect of vaccinating household members of patients with AIIRD were retrieved. Conclusion Evidence on efficacy, immunogenicity and safety of vaccination in patients with AIIRD was systematically reviewed to provide a basis for updated recommendations.

Details

Authors
  • Christien Rondaan
  • Victoria Furer
  • Marloes W. Heijstek
  • Nancy Agmon-Levin
  • Marc Bijl
  • Ferdinand C. Breedveld
  • Raffaele D'Amelio
  • Maxime Dougados
  • Jacob M. Van Laar
  • Annette Ladefoged De Thurah
  • Robert Landewé
  • Anna Molto
  • Ulf Müller-Ladner
  • Karen Schreiber
  • Leo Smolar
  • Jim Walker
  • Klaus Warnatz
  • Nico M. Wulffraat
  • Sander Van Assen
  • Ori Elkayam
Organisations
External organisations
  • University Medical Center Groningen
  • Tel Aviv Sourasky Medical Center – Ichilov Hospital
  • Tel-Aviv University
  • University Medical Center Utrecht
  • Sheba Medical Center
  • Martini Hospital, Groningen
  • Leiden University Medical Centre
  • Sapienza University of Rome
  • Paris Descartes University
  • Skåne University Hospital
  • Aarhus University Hospital
  • Academic Medical Center of University of Amsterdam (AMC)
  • Justus Liebig University Giessen
  • Guy's and St Thomas' NHS Foundation Trust
  • University Medical Center Freiburg
  • Wilhelmina Children’s Hospital
  • Cochin Hospital
  • Zuyderland Medical Centre
  • King Christian the Xth Hospital
  • No affiliation available (private)
  • Treant Zorggroep
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Rheumatology and Autoimmunity
  • Infectious Medicine

Keywords

  • autoimmune diseases, infections, vaccination
Original languageEnglish
Article numbere001035
JournalRMD Open
Volume5
Issue number2
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes