Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants in the rat brain

Research output: Contribution to journalArticle

Abstract

Electrophysiological and pharmacological properties of neurons within solid basal forebrain transplants were studied in adult rats anesthetized with urethane. No specific topography of the neurons recorded was observed within the graft. The mean spontaneous activity of the grafted neurons (GNs) was relatively low (4.9 impulses/s) but not unlike that of other central neurons in situ. A large proportion of GNs fired with regular discharges, but other modes of discharge were also observed. A few rhythmically bursting GNs were recorded having a discharge pattern very much like that of the rhythmically bursting medial septal neurons. The responses of GNs to glutamate, gamma-aminobutyric acid, acetylcholine, serotonin and norepinephrine was fairly similar to those described in other central structures.

Details

Authors
Organisations
External organisations
  • National Institute for Health and Medical Research, France
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Acetylcholine/pharmacology, Animals, Brain/physiology, Carbachol/pharmacology, Electrophysiology/methods, Glutamates/pharmacology, Glutamic Acid, Male, Nerve Tissue/transplantation, Neurons/drug effects, Neurotransmitter Agents/pharmacology, Norepinephrine/pharmacology, Rats, Rats, Inbred Strains, Reference Values, Serotonin/pharmacology, gamma-Aminobutyric Acid/pharmacology
Original languageEnglish
Pages (from-to)8-16
JournalBrain Research
Volume460
Issue number1
Publication statusPublished - 1988 Sep 13
Publication categoryResearch
Peer-reviewedYes