Electrophysiological studies in newly onset type 2 diabetes without visible vascular retinopathy.

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title = "Electrophysiological studies in newly onset type 2 diabetes without visible vascular retinopathy.",
abstract = "The purpose of this study was to investigate the early alterations of retinal function, assessed with electrophysiology, in newly onset type 2 diabetes patients without vascular retinopathy. Seventeen patients with newly diagnosed type 2 diabetes (duration 7 ± 3 months), without any vascular retinopathy in fundus photographs, were examined with full-field electroretinogram (ERG) and multifocal ERG (mfERG). The results were compared with those of age-matched subjects without diabetes. In the dark-adapted full-field ERG, the a-wave and the 30-Hz flicker implicit times were delayed in diabetes patients compared to controls, P = 0.001 and P = 0.020. In the first-order kernel of the mfERG, the first positive wave, P1, was delayed in all areas measured. The electrophysiological examinations demonstrate early alterations of retinal function characterised by a delayed a-wave implicit time in the dark-adapted full-field ERG, representing the rod signalling, and alterations in the multifocal ERG reflecting cone and/or postreceptoral function.",
author = "Maria Tyrberg and Ulf Lindblad and Arne Melander and {L{\"o}vestam Adrian}, Monica and Vesna Ponjavic and Sten Andr{\'e}asson",
year = "2011",
doi = "10.1007/s10633-011-9298-6",
language = "English",
volume = "123",
pages = "193--198",
journal = "Documenta Ophthalmologica",
issn = "1573-2622",
publisher = "Springer",