Electrophysiological studies in newly onset type 2 diabetes without visible vascular retinopathy.

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Electrophysiological studies in newly onset type 2 diabetes without visible vascular retinopathy. / Tyrberg, Maria; Lindblad, Ulf; Melander, Arne; Lövestam Adrian, Monica; Ponjavic, Vesna; Andréasson, Sten.

In: Documenta Ophthalmologica, Vol. 123, 2011, p. 193-198.

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T1 - Electrophysiological studies in newly onset type 2 diabetes without visible vascular retinopathy.

AU - Tyrberg, Maria

AU - Lindblad, Ulf

AU - Melander, Arne

AU - Lövestam Adrian, Monica

AU - Ponjavic, Vesna

AU - Andréasson, Sten

PY - 2011

Y1 - 2011

N2 - The purpose of this study was to investigate the early alterations of retinal function, assessed with electrophysiology, in newly onset type 2 diabetes patients without vascular retinopathy. Seventeen patients with newly diagnosed type 2 diabetes (duration 7 ± 3 months), without any vascular retinopathy in fundus photographs, were examined with full-field electroretinogram (ERG) and multifocal ERG (mfERG). The results were compared with those of age-matched subjects without diabetes. In the dark-adapted full-field ERG, the a-wave and the 30-Hz flicker implicit times were delayed in diabetes patients compared to controls, P = 0.001 and P = 0.020. In the first-order kernel of the mfERG, the first positive wave, P1, was delayed in all areas measured. The electrophysiological examinations demonstrate early alterations of retinal function characterised by a delayed a-wave implicit time in the dark-adapted full-field ERG, representing the rod signalling, and alterations in the multifocal ERG reflecting cone and/or postreceptoral function.

AB - The purpose of this study was to investigate the early alterations of retinal function, assessed with electrophysiology, in newly onset type 2 diabetes patients without vascular retinopathy. Seventeen patients with newly diagnosed type 2 diabetes (duration 7 ± 3 months), without any vascular retinopathy in fundus photographs, were examined with full-field electroretinogram (ERG) and multifocal ERG (mfERG). The results were compared with those of age-matched subjects without diabetes. In the dark-adapted full-field ERG, the a-wave and the 30-Hz flicker implicit times were delayed in diabetes patients compared to controls, P = 0.001 and P = 0.020. In the first-order kernel of the mfERG, the first positive wave, P1, was delayed in all areas measured. The electrophysiological examinations demonstrate early alterations of retinal function characterised by a delayed a-wave implicit time in the dark-adapted full-field ERG, representing the rod signalling, and alterations in the multifocal ERG reflecting cone and/or postreceptoral function.

U2 - 10.1007/s10633-011-9298-6

DO - 10.1007/s10633-011-9298-6

M3 - Article

C2 - 22057379

VL - 123

SP - 193

EP - 198

JO - Documenta Ophthalmologica

JF - Documenta Ophthalmologica

SN - 1573-2622

ER -