Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

Research output: Contribution to journalArticle


Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins and play important roles in development and tissue repair. They have also been shown to have both protective and pathogenic effects in atherosclerosis, and experimental studies have suggested that MMP-12 contributes to plaque growth and destabilization. The objective of this study was to investigate the associations between circulating MMPs, atherosclerosis burden, and incidence of cardiovascular disease with a particular focus on type 2 diabetes mellitus.


  • Helen M Colhoun
  • Angela C Shore
  • Carlo Palombo
  • Andrea Natali
  • Gunilla Nordin Fredrikson
  • Gerd Östling
  • Kunihiko Aizawa
  • Francesco Casanova
  • Kim Gooding
  • David Strain
  • Faisel Kahn
  • Helen C Looker
  • Fiona Adams
  • Jill Belch
  • Silvia Pinnoli
  • Elena Venturi
  • Michaela Kozakova
  • Li-Ming Gan
  • Volker Schnecke
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
Original languageEnglish
Pages (from-to)1723-1731
JournalArteriosclerosis, Thrombosis and Vascular Biology
Issue number7
Publication statusPublished - 2015
Publication categoryResearch