Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

Research output: Contribution to journalArticle


In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.


  • Simone Schleede
  • Felix G. Meinel
  • Martin Bech
  • Julia Herzen
  • Klaus Achterhold
  • Guillaume Potdevin
  • Andreas Malecki
  • Silvia Adam-Neumair
  • Sven F. Thieme
  • Fabian Bamberg
  • Konstantin Nikolaou
  • Alexander Bohla
  • Ali Oe. Yildirim
  • Roderick Loewen
  • Martin Gifford
  • Ronald Ruth
  • Oliver Eickelberg
  • Maximilian Reiser
  • Franz Pfeiffer
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Radiology, Nuclear Medicine and Medical Imaging


  • grating interferometer, pulmonary emphysema, X-ray imaging
Original languageEnglish
Pages (from-to)17880-17885
JournalProceedings of the National Academy of Sciences
Issue number44
Publication statusPublished - 2012
Publication categoryResearch