Enantioselective synthesis of: Anti -3-alkenyl-2-amido-3-hydroxy esters: Application to the total synthesis of (+)-alexine

Research output: Contribution to journalArticle

Abstract

A straightforward synthesis of anti-3-alkenyl-2-amido-3-hydroxy esters from the corresponding racemic α-amino-β-keto esters by using a ATH/DKR protocol has been developed. This method gives moderate to excellent yields with high chemo-, diastereo- and enantioselectivities for a broad range of substrates. In order to highlight the versatility of the methodology it was applied in an efficient asymmetric synthesis of the polyhydroxylated pyrrolizidine alkaloid (+)-alexine.

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Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry
Original languageEnglish
Pages (from-to)2799-2802
Number of pages4
JournalRSC Advances
Volume9
Issue number5
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes

Related research output

Lu Yu, 2019 Aug 27, Lund: Printed in Sweden by Media-Tryck, Lund University. 142 p.

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