Enantioselective Synthesis of Substituted Piperidines by Addition of Aryl Grignard Reagents to Pyridine N-Oxides.

Research output: Contribution to journalArticle


The synthesis of optically active piperidines by enantioselective addition of aryl Grignard reagents to pyridine N-oxides and lithium binolate followed by reduction is reported for the first time. The reaction results in high yields (51-94%) in combination with good ee (54-80%). Some of these products were subsequently recrystallized, affording enhanced optical purities (>99% ee).


  • Munawar Hussain
  • Thomas Sainte-Luce Banchelin
  • Hans Andersson
  • Roger Olsson
  • Fredrik Almqvist
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry
Original languageEnglish
JournalOrganic Letters
Early online date2012 Dec 20
Publication statusPublished - 2012
Publication categoryResearch