Endocrine therapy resistance in estrogen receptor (ER)-positive breast cancer

Research output: Contribution to journalReview article


Estrogen receptor (ER)-positive breast cancer represents the majority (∼70%) of all breast malignancies. In this subgroup of breast cancers, endocrine therapies are effective both in the adjuvant and recurrent settings, although resistance remains a major issue. Several high-throughput approaches have been used to elucidate mechanisms of resistance and to derive potential predictive markers or alternative therapies. In this review, we cover the state-of-the-art of endocrine-resistance biomarker discovery with regard to the latest technological developments, and discuss current opportunities and restrictions for their implementation into a clinical setting.


External organisations
  • Erasmus University Medical Center
Original languageEnglish
Pages (from-to)1181-8
Number of pages8
JournalDrug Discovery Today
Issue number7
Publication statusPublished - 2016 Jul
Publication categoryResearch
Externally publishedYes