Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice

Research output: Contribution to journalArticle

Abstract

NKT cells m the mouse recognize antigen in the context of the MHC class I-like molecule CD1d and play an important role in peripheral tolerance and protection against autoimmune and other diseases NKT cells are usually activated by CD1d-presented lipid antigens However, peptide recognition m the context of CD 1 has also been documented, although no self-peptide ligands have been reported to date Here, we have identified an endogenous peptide that is presented by CD1d to activate mouse NKT cells This peptide, the immunodominant epitope from mouse collagen type II (mCII(707-721)), was not associated with either MHC class I or II Activation of CD1d-restricted mCII(707-721)-specific NKT cells was induced via TCR signaling and classical costimulation hi addition, mCII(707-721)-specific NKT cells induced T cell death through Fas/FasL, man IL-17A-independent fashion Moreover, mCII(707-721)-specific NKT cells suppressed a range of in vivo inflammatory conditions, including delayed-type hypersensitivity, antigen-induced airway inflammation, collagen-induced arthritis, and EAE, which were all ameliorated by mCII(707) (721) vaccination The findings presented here offer new insight into the intrinsic roles of NKT cells in health and disease Given the results, endogenous collagen peptide activators of NKT cells may offer promise as novel therapeutics in tissue-specific autoimmune and inflammatory diseases

Details

Authors
  • Yawei Liu
  • Anna Teige
  • Emma Mondoc
  • Saleh Ibrahim
  • Rikard Holmdahl
  • Shohreh Issazadeh
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Immunology in the medical area
  • Neurosciences
Original languageEnglish
Pages (from-to)249-264
JournalJournal of Clinical Investigation
Volume121
Issue number1
Publication statusPublished - 2011
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019), Neuroinflammation (013210006)

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Anna Teige, 2014, Department of Clinical Sciences, Lund University. 59 p.

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