Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European Male Ageing Study

Research output: Contribution to journalArticle

Abstract

Objective: Data remain divergent regarding the activational effects of endogenous hormones on adult cognitive function. We examined the association between cognition, hormones and androgen receptor (AR) CAG repeat length in a large cohort of men. Design: Community-based, cross-sectional study of 3369 men aged 40-79 years. Methods: Cognition tests were the Rey-Osterrieth Complex Figure, Camden Topographical Recognition Memory and Digit-Symbol Substitution. A fluid cognition (FC) z-score was computed from the individual tests. Testosterone, oestradiol (OE2) and 5 alpha-dihydrotestosterone were measured by gas chromatography-mass spectrometry; DHEAS, LH, FSH and sex hormone-binding globulin (SHBG) by electrochemiluminescence. Free testosterone and OE2 were calculated from total hormone, SHBG and albumin. CAG repeat lengths were assayed by PCR genotyping. Results: Total testosterone and free testosterone were associated with higher FC z-scores, LH and FSH with lower FC z-scores in age-adjusted linear regressions. After adjusting for health, lifestyle and centre, a modest association was only observed between DHEAS and a lower FC z-score (beta=-0.011, P=0.02), although this was driven by subjects with DHEAS levels > 10 mu mol/l. Locally weighted plots revealed no threshold effects between hormones and FC. There was no association between CAG repeat length and FC z-score after adjustment for age and centre (beta=-0.007, P=0.06), nor any interaction effect between CAG repeat length and hormones. Conclusion: Our results suggest that endogenous hormones are not associated with a vision-based measure of FC among healthy, community-dwelling men. Further studies are warranted to determine whether 'high' DHEAS levels are associated with poorer performance on a broader range of neuropsychological tests.

Details

Authors
  • David M. Lee
  • Aslan Ulubaev
  • Abdelouahid Tajar
  • Stephen R. Pye
  • Neil Pendleton
  • Nitin Purandare
  • Terence W. O'Neill
  • Daryl B. O'Connor
  • Fernand Labrie
  • Hazel Platt
  • Debbie Payne
  • Gyorgy Bartfai
  • Steven Boonen
  • Felipe F. Casanueva
  • Joseph D. Finn
  • Gianni Forti
  • Thang S. Han
  • Ilpo T. Huhtaniemi
  • Krzysztof Kula
  • Michael E. J. Lean
  • Margus Punab
  • Alan J. Silman
  • Dirk Vanderschueren
  • Frederick C. W. Wu
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
Original languageEnglish
Pages (from-to)1155-1164
JournalEuropean Journal of Endocrinology
Volume162
Issue number6
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes