Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies

Research output: Contribution to journalArticle

Abstract

Skin fibrosis is characterized by activated fibroblasts and an altered architecture of the extracellular matrix. Excessive deposition of extracellular matrix proteins and altered cytokine levels in the dermal collagen matrix are common to several pathological situations such as localized scleroderma and systemic sclerosis, keloids, dermatosclerosis associated with venous ulcers and the fibroproliferative tissue surrounding invasively growing tumors. Which factors contribute to altered organization of dermal collagen matrix in skin fibrosis is not well understood. We recently demonstrated that cartilage oligomeric matrix protein (COMP) functions as organizer of the dermal collagen I network in healthy human skin (Agarwal et al., 2012). Here we show that COMP deposition is enhanced in the dermis in various fibrotic conditions. COMP levels were significantly increased in fibrotic lesions derived from patients with localized scleroderma, in wound tissue and exudates of patients with venous leg ulcers and in the fibrotic stroma of biopsies from patients with basal cell carcinoma. We postulate enhanced deposition of COMP as one of the common factors altering the supramolecular architecture of collagen matrix in fibrotic skin pathologies. Interestingly, COMP remained nearly undetectable in normally healing wounds where myofibroblasts transiently accumulate in the granulation tissue. We conclude that COMP expression is restricted to a fibroblast differentiation state not identical to myofibroblasts which is induced by TGF beta and biomechanical forces. (C) 2013 Elsevier B.V. All rights reserved.

Details

Authors
  • Pallavi Agarwal
  • Jan-Niklas Schulz
  • Katrin Blumbach
  • Kristofer Andréasson
  • Dick Heinegård
  • Mats Paulsson
  • Cornelia Mauch
  • Sabine A. Eming
  • Beate Eckes
  • Thomas Krieg
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Rheumatology and Autoimmunity

Keywords

  • COMP, ECM organization, Collagen fibrils, Basal cell carcinoma, Chronic, wounds, Fibroplastic stroma response
Original languageEnglish
Pages (from-to)325-331
JournalMatrix Biology
Volume32
Issue number6
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes