Enhanced expression of iNOS intratumorally and at the immunization site after immunization with IFNgamma-secreting rat glioma cells

Research output: Contribution to journalArticle

Abstract

Nitric oxide (NO) can modulate both tumor growth and antitumor immune responses. In order to elucidate the mechanism of curative therapeutic immunization with IFNgamma-producing glioma cells, we examined the expression of inducible nitric oxide synthase (iNOS) in tissue sections from immunized animals. There was a significantly enhanced iNOS expression both intratumorally and at the immunization site. Although the mechanisms behind this dual expression of iNOS most probably are different, our results suggest a role for NO in both the induction and execution of the antitumor response.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
  • Immunology in the medical area

Keywords

  • Cells, Cultured, Brain Neoplasms/*enzymology/immunology, Glioma/*immunology, Immunization, Interferon Type II/*biosynthesis, Lymph Nodes/enzymology, Male, Nitric Oxide/*physiology, Nitric-Oxide Synthase/*biosynthesis, Phagocytosis, Rats, Inbred F344, Skin/enzymology, Support, Non-U.S. Gov't, Spleen/enzymology, Animal
Original languageEnglish
Article number123
Pages (from-to)135-143
Number of pages9
JournalJournal of Neuroimmunology
Volume123
Issue number1-2
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurosurgery (013026000), Genetics (Closed 2011) (011005100)