Enriched environment downregulates macrophage migration inhibitory factor and increases parvalbumin in the brain following experimental stroke

Research output: Contribution to journalArticle


Housing rodents in an enriched environment (EE) following experimental stroke enhances neurological recovery. Understanding the underlying neural cues may provide the basis for improving stroke rehabilitation. We studied the contribution of brain macrophage migration inhibitory factor (MIF) to functional recovery after permanent middle cerebral artery occlusion (pMCAo) in rats. In the cerebral cortex, MIF is predominantly found in neurons, particularly in parvalbumin interneurons. Following pMCAo, MIF increases around the infarct core, where it is located to neurons and astrocytes. Housing rats in an EE after pMCAo resulted in a decrease of MIF protein levels in pen-infarct areas, which was accompanied by an increase in parvalbumin immunoreactive interneurons. Our data suggest that MIF is part of a signaling network involved in brain plasticity, and elevated neuronal and/or astrocytic MIF levels repress the recovery of sensory-motor function after stroke. Downregulating MIF could constitute a new therapeutic approach to promote recovery after stroke. (C) 2010 Elsevier Inc. All rights reserved.


Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences


  • Astrocytes, Enriched environment, Experimental stroke, Functional, recovery, Macrophage migration inhibitory factor, Parvalbumin, Spontaneously hypertensive rats
Original languageEnglish
Pages (from-to)270-278
JournalNeurobiology of Disease
Issue number2
Publication statusPublished - 2011
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Laboratory for Experimental Brain Research (013041000)

Related research output

Inacio, A., 2011, Laboratory for Experimental Brain Research. 188 p.

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