Enzymatic characterization of lipid-based drug delivery systems

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Enzymatic characterization of lipid-based drug delivery systems. / Ljusberg, Helena; Nielsen, F S; Brogard, M; Troedsson, Emma; Mullertz, A.

In: International Journal of Pharmaceutics, Vol. 298, No. 2, 2005, p. 328-332.

Research output: Contribution to journalArticle

Harvard

Ljusberg, H, Nielsen, FS, Brogard, M, Troedsson, E & Mullertz, A 2005, 'Enzymatic characterization of lipid-based drug delivery systems', International Journal of Pharmaceutics, vol. 298, no. 2, pp. 328-332. https://doi.org/10.1016/j.ijpharm.2005.02.038

APA

Ljusberg, H., Nielsen, F. S., Brogard, M., Troedsson, E., & Mullertz, A. (2005). Enzymatic characterization of lipid-based drug delivery systems. International Journal of Pharmaceutics, 298(2), 328-332. https://doi.org/10.1016/j.ijpharm.2005.02.038

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Author

Ljusberg, Helena ; Nielsen, F S ; Brogard, M ; Troedsson, Emma ; Mullertz, A. / Enzymatic characterization of lipid-based drug delivery systems. In: International Journal of Pharmaceutics. 2005 ; Vol. 298, No. 2. pp. 328-332.

RIS

TY - JOUR

T1 - Enzymatic characterization of lipid-based drug delivery systems

AU - Ljusberg, Helena

AU - Nielsen, F S

AU - Brogard, M

AU - Troedsson, Emma

AU - Mullertz, A

PY - 2005

Y1 - 2005

N2 - The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model drugs, probucol and halofantrine, into the SMEDDS was studied. It was found that both model drugs reduced the initial rate of lipolysis compared with the vehicle, probucol having a larger effect than halofantrine. The reduction of initial lipolysis rate indicates that probucol and halofantrine are bound in the water/emulsion interface limiting the substrate availability.

AB - The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model drugs, probucol and halofantrine, into the SMEDDS was studied. It was found that both model drugs reduced the initial rate of lipolysis compared with the vehicle, probucol having a larger effect than halofantrine. The reduction of initial lipolysis rate indicates that probucol and halofantrine are bound in the water/emulsion interface limiting the substrate availability.

KW - Self-microemulsifying drug delivery system

KW - Lipolysis

KW - Probucol

KW - Halofantrine

U2 - 10.1016/j.ijpharm.2005.02.038

DO - 10.1016/j.ijpharm.2005.02.038

M3 - Article

VL - 298

SP - 328

EP - 332

JO - International Journal of Pharmaceutics

T2 - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 1873-3476

IS - 2

ER -