Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke

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Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke. / Sundström, Johannes; Söderholm, Martin; Borné, Yan; Nilsson, Jan; Persson, Margaretha; Östling, Gerd; Melander, Olle; Orho-Melander, Marju; Engström, Gunnar.

In: Stroke, Vol. 48, No. 10, 01.10.2017, p. 2686-2692.

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TY - JOUR

T1 - Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke

AU - Sundström, Johannes

AU - Söderholm, Martin

AU - Borné, Yan

AU - Nilsson, Jan

AU - Persson, Margaretha

AU - Östling, Gerd

AU - Melander, Olle

AU - Orho-Melander, Marju

AU - Engström, Gunnar

PY - 2017/10/1

Y1 - 2017/10/1

N2 - BACKGROUND AND PURPOSE: ECP (eosinophil cationic protein) is a marker of eosinophil activity and degranulation, which has been linked to atherosclerosis and cardiovascular disease. We examined the relationship between ECP, carotid plaque, and incidence of stroke in a prospective population-based cohort.METHODS: The subjects participated in the Malmö Diet and Cancer Study between 1991 and 1994. A total of 4706 subjects with no history of stroke were included (40% men; mean age, 57.5 years). Carotid plaque was determined by B-mode ultrasound of the right carotid artery. Incidence of stroke was followed up during a mean period of 16.5 years in relation to plasma ECP levels.RESULTS: Subjects in the third tertile (versus first tertile) of ECP tended to have higher prevalence of carotid plaque (odds ratio: 1.18; 95% confidence interval: 1.003-1.39; P=0.044 after multivariate adjustments). A total of 258 subjects were diagnosed with ischemic stroke (IS) during follow-up. ECP was associated with increased incidence of IS after risk factor adjustment (hazard ratio, 1.57; 95% confidence interval: 1.13-2.18; for third versus first tertile; P=0.007). High ECP was associated with increased risk of IS in subjects with carotid plaque. The risk factor-adjusted hazard ratio for IS was 1.86 (95% confidence interval: 1.32-2.63) in subjects with carotid plaque and ECP in the top tertile, compared with those without plaque and ECP in the first or second tertiles.CONCLUSIONS: High ECP is associated with increased incidence of IS. The association between ECP and IS was also present in the subgroup with carotid plaque.

AB - BACKGROUND AND PURPOSE: ECP (eosinophil cationic protein) is a marker of eosinophil activity and degranulation, which has been linked to atherosclerosis and cardiovascular disease. We examined the relationship between ECP, carotid plaque, and incidence of stroke in a prospective population-based cohort.METHODS: The subjects participated in the Malmö Diet and Cancer Study between 1991 and 1994. A total of 4706 subjects with no history of stroke were included (40% men; mean age, 57.5 years). Carotid plaque was determined by B-mode ultrasound of the right carotid artery. Incidence of stroke was followed up during a mean period of 16.5 years in relation to plasma ECP levels.RESULTS: Subjects in the third tertile (versus first tertile) of ECP tended to have higher prevalence of carotid plaque (odds ratio: 1.18; 95% confidence interval: 1.003-1.39; P=0.044 after multivariate adjustments). A total of 258 subjects were diagnosed with ischemic stroke (IS) during follow-up. ECP was associated with increased incidence of IS after risk factor adjustment (hazard ratio, 1.57; 95% confidence interval: 1.13-2.18; for third versus first tertile; P=0.007). High ECP was associated with increased risk of IS in subjects with carotid plaque. The risk factor-adjusted hazard ratio for IS was 1.86 (95% confidence interval: 1.32-2.63) in subjects with carotid plaque and ECP in the top tertile, compared with those without plaque and ECP in the first or second tertiles.CONCLUSIONS: High ECP is associated with increased incidence of IS. The association between ECP and IS was also present in the subgroup with carotid plaque.

KW - cohort studies

KW - eosinophil cationic protein

KW - epidemiology

KW - risk factors

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=85030995981&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.117.018450

DO - 10.1161/STROKEAHA.117.018450

M3 - Article

VL - 48

SP - 2686

EP - 2692

JO - Stroke: a journal of cerebral circulation

T2 - Stroke: a journal of cerebral circulation

JF - Stroke: a journal of cerebral circulation

SN - 1524-4628

IS - 10

ER -