Epidemiology of biopsy-confirmed giant cell arteritis in southern Sweden - an update on incidence and first prevalence estimate

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@article{647d2a99cc484d8dbd361ad765f090d9,
title = "Epidemiology of biopsy-confirmed giant cell arteritis in southern Sweden - an update on incidence and first prevalence estimate",
abstract = "AbstractObjectiveTo characterize the epidemiology of temporal artery biopsy–positive (TAB+) giant cell arteritis (GCA), including trends in incidence, seasonal variation, and prevalence in Sk{\aa}ne, the southernmost region of Sweden.MethodsAll histopathology reports of TABs from 1997 through 2019 were reviewed to identify patients diagnosed with TAB+ GCA. Incidence rates based on the 23-year period and the point-prevalence at 31 December, 2014 were determined. An alternative prevalence calculation included only TAB+ GCA patients living in the study area and receiving immunosuppressant therapy on the point-prevalence date.Results1360 patients were diagnosed with TAB+ GCA (71% female). The average annual incidence 1997–2019 was 13.3 (95% CI 12.6–14.0) per 100 000 inhabitants aged ≥50 years and was higher in females (17.8; 95% CI 16.7–18.9) than in males (8.2; 95% CI 7.4–9.0). The age- and sex- standardized incidence declined from 17.3 in 1997–8.7 in 2019, with incidence ratio (IR) of 0.98 per year (95% CI 0.98–0.99). A seasonal variation was observed with higher incidence during spring than winter [IR 1.19 (95% CI 1.03–1.39)]. The overall point-prevalence of TAB+ GCA was 127.1 per 100 000 (95% CI 117–137.3) and was 75.5 (95% CI 67.7–83.3) when including only patients receiving immunosuppressants.ConclusionsOver the past two decades, the incidence of biopsy-confirmed GCA has decreased by ∼2% per year. Still, a high prevalence of GCA on current treatment was observed. More cases are diagnosed during spring and summer than in the winter.",
author = "Pavlos Stamatis and Aleksandra Turkiewicz and Martin Englund and Carl Turesson and Aladdin Mohammad",
year = "2021",
month = mar,
day = "18",
doi = "10.1093/rheumatology/keab269",
language = "English",
journal = "Rheumatology",
issn = "1462-0332",
publisher = "Oxford University Press",

}