Establishing outcome measures in early knee osteoarthritis

Research output: Contribution to journalReview article


The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.


  • Carolyn A Emery
  • Jackie L Whittaker
  • Armaghan Mahmoudian
  • Ewa M Roos
  • Kim L Bennell
  • Clodagh M Toomey
  • Raylene A Reimer
  • Dylan Thompson
  • Janet L Ronsky
  • Gregor Kuntze
  • David G Lloyd
  • Thomas Andriacchi
  • Virginia B Kraus
  • Elena Losina
  • Sita Bierma-Zeinstra
  • Jos Runhaar
  • George Peat
  • Frank P Luyten
  • Lynn Snyder-Mackler
  • May Arna Risberg
  • Ali Mobasheri
  • Ali Guermazi
  • David J Hunter
  • Nigel K Arden
External organisations
  • VA Palo Alto Health Care System
  • Keele University
  • Queen's Medical Centre, Nottingham
  • Boston University
  • Oxford Brookes University
  • University of Calgary
  • University of Alberta
  • Skåne University Hospital
  • University Hospitals Leuven
  • University of Southern Denmark
  • University of Melbourne
  • University of Bath
  • Griffith University
  • Duke University
  • Harvard University
  • Brigham and Women's Hospital, Boston
  • Erasmus University Medical Center
  • University of Delaware
  • Oslo university hospital
  • University of Sydney
  • Royal North Shore Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Orthopedics
Original languageEnglish
Pages (from-to)438-448
JournalNature Reviews Rheumatology
Issue number7
Early online date2019 Jun 14
Publication statusPublished - 2019
Publication categoryResearch