Establishing outcome measures in early knee osteoarthritis

Research output: Contribution to journalReview article


title = "Establishing outcome measures in early knee osteoarthritis",
abstract = "The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.",
author = "Emery, {Carolyn A} and Whittaker, {Jackie L} and Armaghan Mahmoudian and Lohmander, {L Stefan} and Roos, {Ewa M} and Bennell, {Kim L} and Toomey, {Clodagh M} and Reimer, {Raylene A} and Dylan Thompson and Ronsky, {Janet L} and Gregor Kuntze and Lloyd, {David G} and Thomas Andriacchi and Martin Englund and Kraus, {Virginia B} and Elena Losina and Sita Bierma-Zeinstra and Jos Runhaar and George Peat and Luyten, {Frank P} and Lynn Snyder-Mackler and Risberg, {May Arna} and Ali Mobasheri and Ali Guermazi and Hunter, {David J} and Arden, {Nigel K}",
year = "2019",
doi = "10.1038/s41584-019-0237-3",
language = "English",
volume = "15",
pages = "438--448",
journal = "Nature Reviews Rheumatology",
issn = "1759-4804",
publisher = "Nature Publishing Group",
number = "7",