Establishing outcome measures in early knee osteoarthritis

Research output: Contribution to journalReview article

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Establishing outcome measures in early knee osteoarthritis. / Emery, Carolyn A; Whittaker, Jackie L; Mahmoudian, Armaghan; Lohmander, L Stefan; Roos, Ewa M; Bennell, Kim L; Toomey, Clodagh M; Reimer, Raylene A; Thompson, Dylan; Ronsky, Janet L; Kuntze, Gregor; Lloyd, David G; Andriacchi, Thomas; Englund, Martin; Kraus, Virginia B; Losina, Elena; Bierma-Zeinstra, Sita; Runhaar, Jos; Peat, George; Luyten, Frank P; Snyder-Mackler, Lynn; Risberg, May Arna; Mobasheri, Ali; Guermazi, Ali; Hunter, David J; Arden, Nigel K.

In: Nature Reviews Rheumatology, Vol. 15, No. 7, 2019, p. 438-448.

Research output: Contribution to journalReview article

Harvard

Emery, CA, Whittaker, JL, Mahmoudian, A, Lohmander, LS, Roos, EM, Bennell, KL, Toomey, CM, Reimer, RA, Thompson, D, Ronsky, JL, Kuntze, G, Lloyd, DG, Andriacchi, T, Englund, M, Kraus, VB, Losina, E, Bierma-Zeinstra, S, Runhaar, J, Peat, G, Luyten, FP, Snyder-Mackler, L, Risberg, MA, Mobasheri, A, Guermazi, A, Hunter, DJ & Arden, NK 2019, 'Establishing outcome measures in early knee osteoarthritis', Nature Reviews Rheumatology, vol. 15, no. 7, pp. 438-448. https://doi.org/10.1038/s41584-019-0237-3

APA

Emery, C. A., Whittaker, J. L., Mahmoudian, A., Lohmander, L. S., Roos, E. M., Bennell, K. L., ... Arden, N. K. (2019). Establishing outcome measures in early knee osteoarthritis. Nature Reviews Rheumatology, 15(7), 438-448. https://doi.org/10.1038/s41584-019-0237-3

CBE

Emery CA, Whittaker JL, Mahmoudian A, Lohmander LS, Roos EM, Bennell KL, Toomey CM, Reimer RA, Thompson D, Ronsky JL, Kuntze G, Lloyd DG, Andriacchi T, Englund M, Kraus VB, Losina E, Bierma-Zeinstra S, Runhaar J, Peat G, Luyten FP, Snyder-Mackler L, Risberg MA, Mobasheri A, Guermazi A, Hunter DJ, Arden NK. 2019. Establishing outcome measures in early knee osteoarthritis. Nature Reviews Rheumatology. 15(7):438-448. https://doi.org/10.1038/s41584-019-0237-3

MLA

Vancouver

Author

Emery, Carolyn A ; Whittaker, Jackie L ; Mahmoudian, Armaghan ; Lohmander, L Stefan ; Roos, Ewa M ; Bennell, Kim L ; Toomey, Clodagh M ; Reimer, Raylene A ; Thompson, Dylan ; Ronsky, Janet L ; Kuntze, Gregor ; Lloyd, David G ; Andriacchi, Thomas ; Englund, Martin ; Kraus, Virginia B ; Losina, Elena ; Bierma-Zeinstra, Sita ; Runhaar, Jos ; Peat, George ; Luyten, Frank P ; Snyder-Mackler, Lynn ; Risberg, May Arna ; Mobasheri, Ali ; Guermazi, Ali ; Hunter, David J ; Arden, Nigel K. / Establishing outcome measures in early knee osteoarthritis. In: Nature Reviews Rheumatology. 2019 ; Vol. 15, No. 7. pp. 438-448.

RIS

TY - JOUR

T1 - Establishing outcome measures in early knee osteoarthritis

AU - Emery, Carolyn A

AU - Whittaker, Jackie L

AU - Mahmoudian, Armaghan

AU - Lohmander, L Stefan

AU - Roos, Ewa M

AU - Bennell, Kim L

AU - Toomey, Clodagh M

AU - Reimer, Raylene A

AU - Thompson, Dylan

AU - Ronsky, Janet L

AU - Kuntze, Gregor

AU - Lloyd, David G

AU - Andriacchi, Thomas

AU - Englund, Martin

AU - Kraus, Virginia B

AU - Losina, Elena

AU - Bierma-Zeinstra, Sita

AU - Runhaar, Jos

AU - Peat, George

AU - Luyten, Frank P

AU - Snyder-Mackler, Lynn

AU - Risberg, May Arna

AU - Mobasheri, Ali

AU - Guermazi, Ali

AU - Hunter, David J

AU - Arden, Nigel K

PY - 2019

Y1 - 2019

N2 - The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.

AB - The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.

U2 - 10.1038/s41584-019-0237-3

DO - 10.1038/s41584-019-0237-3

M3 - Review article

VL - 15

SP - 438

EP - 448

JO - Nature Reviews Rheumatology

JF - Nature Reviews Rheumatology

SN - 1759-4804

IS - 7

ER -