Ethanol intake and risk of lung cancer in the European prospective investigation into cancer and nutrition (EPIC)

Research output: Contribution to journalArticle


Within the European Prospective Investigation into Cancer and Nutrition (EPIC), the authors examined the association of ethanol intake at recruitment (1,119 cases) and mean lifelong ethanol intake (887 cases) with lung cancer. Information on baseline and past alcohol consumption, lifetime tobacco smoking, diet, and the anthropometric characteristics of 478,590 participants was collected between 1992 and 2000. Cox proportional hazards regression was used to calculate multivariate-adjusted hazard ratios and 95% confidence intervals. Overall, neither ethanol intake at recruitment nor mean lifelong ethanol intake was significantly associated with lung cancer. However, moderate intake (5-14.9 g/day) at recruitment (hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.63, 0.90) and moderate mean lifelong intake (HR = 0.80, 95% CI: 0.66, 0.97) were associated with a lower lung cancer risk in comparison with low consumption (0.1-4.9 g/day). Compared with low intake, a high (>= 60 g/day) mean lifelong ethanol intake tended to be related to a higher risk of lung cancer (HR = 1.29, 95% CI: 0.93, 1.74), but high intake at recruitment was not. Although there was no overall association between ethanol intake and risk of lung cancer, the authors cannot rule out a lower risk for moderate consumption and a possibly increased risk for high lifelong consumption.


  • Sabine Rohrmann
  • Jakob Linseisen
  • Hendriek C. Boshuizen
  • John Whittaker
  • Antonio Agudo
  • Paolo Vineis
  • Paolo Boffetta
  • Majken K. Jensen
  • Anja Olsen
  • Kim Overvad
  • Anne Tjonneland
  • Marie-Christine Boutron-Ruault
  • Francoise Clavel-Chapelon
  • Manuela M. Bergmann
  • Heiner Boeing
  • Naomi Allen
  • Tim Key
  • Sheila Bingham
  • Kay-Tee Khaw
  • Georgia Kyriazi
  • And 24 others
  • Stavroula Soukara
  • Antonia Trichopoulou
  • Salvatore Panico
  • Domenico Palli
  • Sabina Sieri
  • Rosario Tumino
  • Petra H. M. Peeters
  • H. Bas Bueno-de-Mesquita
  • Frederike L. Buchner
  • Inger Torhild Gram
  • Eiliv Lund
  • Eva Ardanaz
  • Maria-Dolores Chirlaque
  • Miren Dorronsoro
  • Maria-Jose Sanchez Perez
  • Jose R. Quiros
  • Göran Berglund
  • Lars Janzon
  • Torgny Rasmuson
  • Lars Weinehall
  • Pietro Ferrari
  • Mazda Jenab
  • Teresa Norat
  • Elio Riboli
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Public Health, Global Health, Social Medicine and Epidemiology


  • lung neoplasms, cohort studies, ethanol, alcohol drinking
Original languageEnglish
Pages (from-to)1103-1114
JournalAmerican Journal of Epidemiology
Issue number11
Publication statusPublished - 2006
Publication categoryResearch