European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

Research output: Contribution to journalArticle

Abstract

Introduction: The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND comprises 22 European and one US site, including over 50 MRI and dementia experts as well as neuroscientists. Methods: EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical research, highest resolution anatomy, functional imaging, vascular systems/vascular pathology, iron mapping and neuropathology detection, spectroscopy, and quality assurance. Across these topics, EUFIND considered standard operating procedures, safety, and multivendor harmonization. Results: The clinical and research opportunities and challenges of 7T MRI in each subtopic are set out as a roadmap. Specific MRI sequences for each subtopic were implemented in a pilot study presented in this report. Results show that a large multisite 7T imaging network with highly advanced and harmonized imaging sequences is feasible and may enable future multicentre ultrahigh-field MRI studies and clinical trials. Discussion: The EUFIND network can be a major driver for advancing clinical neuroimaging research using 7T and for identifying use-cases for clinical applications in neurodegeneration.

Details

Authors
  • Emrah Düzel
  • Julio Acosta-Cabronero
  • Geert Jan Biessels
  • Michel Bottlaender
  • Richard Bowtell
  • Mark v. Buchem
  • Arturo Cardenas-Blanco
  • Fawzi Boumezbeur
  • Dennis Chan
  • Stuart Clare
  • Mauro Costagli
  • Ludovic de Rochefort
  • Ariane Fillmer
  • Penny Gowland
  • Jeroen Hendrikse
  • Oliver Kraff
  • Mark E. Ladd
  • Itamar Ronen
  • Esben Petersen
  • James B. Rowe
  • Hartwig Siebner
  • Tony Stoecker
  • Sina Straub
  • Michela Tosetti
  • Kamil Uludag
  • Alexandre Vignaud
  • Jaco Zwanenburg
  • Oliver Speck
Organisations
External organisations
  • Otto von Guericke University Magdeburg
  • German Center for Neurodegenerative Diseases (DZNE), Bonn
  • University College London
  • University Medical Center Utrecht
  • Sahlgrenska Academy
  • University of Paris-Saclay
  • University of Nottingham
  • Leiden University Medical Centre
  • University of Cambridge
  • University of Oxford
  • Physikalisch-Technische Bundesanstalt
  • Skåne University Hospital
  • University of Duisburg-Essen
  • German Cancer Research Centre
  • Heidelberg University
  • Hvidovre Hospital
  • Bispebjerg Hospital
  • Sungkyunkwan University
  • IRCCS Stella Maris
  • Aix-Marseille University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Radiology, Nuclear Medicine and Medical Imaging
  • Neurology

Keywords

  • Alzheimer's disease (AD), Magnetic resonance imaging (MRI), Mild cognitive impairment (MCI), Parkinson's disease (PD), Subjective cognitive decline (SCD), Ultrahigh-field MRI, Vascular dementia
Original languageEnglish
Pages (from-to)538-549
Number of pages12
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
Publication statusPublished - 2019 Dec 1
Publication categoryResearch
Peer-reviewedYes