Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis

Research output: Contribution to journalArticle

Abstract

A new fluorescent analog to the antiproliferative 2-(6-hydroxynaphthyl)-beta-D-xylopyranoside has been synthesized and tested on a T24 cell line. The new analog was efficiently uptaken by the T24 cells but did not initiate priming of GAG chains. The results are similar to other fluorescently labeled analogs and we propose that these compounds are too large and unpolar to efficiently function as GAG-primers. (c) 2007 Elsevier Ltd. All rights reserved.

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Authors
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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medicinal Chemistry

Keywords

  • glycosaminoglycan, fluorescent, carbohydrates, xylose, proteoglycan
Original languageEnglish
Pages (from-to)2338-2341
JournalBioorganic & Medicinal Chemistry Letters
Volume17
Issue number8
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Glycobiology (013212006)