Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis

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Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis. / Johnsson, Richard; Mani, Katrin; Ellervik, Ulf.

In: Bioorganic & Medicinal Chemistry Letters, Vol. 17, No. 8, 2007, p. 2338-2341.

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TY - JOUR

T1 - Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis

AU - Johnsson, Richard

AU - Mani, Katrin

AU - Ellervik, Ulf

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Glycobiology (013212006)

PY - 2007

Y1 - 2007

N2 - A new fluorescent analog to the antiproliferative 2-(6-hydroxynaphthyl)-beta-D-xylopyranoside has been synthesized and tested on a T24 cell line. The new analog was efficiently uptaken by the T24 cells but did not initiate priming of GAG chains. The results are similar to other fluorescently labeled analogs and we propose that these compounds are too large and unpolar to efficiently function as GAG-primers. (c) 2007 Elsevier Ltd. All rights reserved.

AB - A new fluorescent analog to the antiproliferative 2-(6-hydroxynaphthyl)-beta-D-xylopyranoside has been synthesized and tested on a T24 cell line. The new analog was efficiently uptaken by the T24 cells but did not initiate priming of GAG chains. The results are similar to other fluorescently labeled analogs and we propose that these compounds are too large and unpolar to efficiently function as GAG-primers. (c) 2007 Elsevier Ltd. All rights reserved.

KW - glycosaminoglycan

KW - fluorescent

KW - carbohydrates

KW - xylose

KW - proteoglycan

U2 - 10.1016/j.bmcl.2007.01.063

DO - 10.1016/j.bmcl.2007.01.063

M3 - Article

VL - 17

SP - 2338

EP - 2341

JO - Bioorganic and Medicinal Chemistry Letters

T2 - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 1090-2120

IS - 8

ER -