Evidence for a GABA-mediated cerebellar inhibition of the inferior olive in the cat

Research output: Contribution to journalArticle

Abstract

1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition is mediated by a GABA-ergic interposito-olivary pathway.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Cerebellum, Inferior olive, Interposito-olivary pathway, Brachium conjunctivum, GABA
Original languageEnglish
Pages (from-to)450-456
JournalExperimental Brain Research
Volume72
Issue number3
Publication statusPublished - 1988
Publication categoryResearch
Peer-reviewedYes